abstract：:Long noncoding RNA (lncRNA) differentiation antagonizing nonprotein coding RNA (DANCR) plays important regulatory roles in many solid tumors. However, the effect of DANCR in glioma progression and underlying molecular mechanisms were not entirely explored. In the present study, we determined the expression of DANCR in...

journal_title：Bioscience reports

authors： Xu D,Yu J,Gao G,Lu G,Zhang Y,Ma P

更新日期：2018-02-02 00:00:00

abstract：:The present study was conducted with the aim being to investigate the effect γ-aminobutyric acid type B (GABAB) receptor activation have on spatial cognitive function and hippocampal neurones found in the rat models of type 2 diabetes mellitus (T2DM). T2DM rat models were then established, randomized, and subsequently...

journal_title：Bioscience reports

authors： Cai XJ,Wang L,Hu CM

更新日期：2018-01-19 00:00:00

abstract：:PU box binding protein (PU.1) is a critical transcription factor involved in many pathological processes. However, its exact role in activation of hepatic stellate cells (HSCs) and liver fibrosis was rarely reported. Here, we found that, in HSCs of PU.1+/- mice, Sirt1 mRNA expression was not changed but Sirt1 protein ...

journal_title：Bioscience reports

authors： Liu Q,Zhang Y,Yang S,Wu Y,Wang J,Yu W,Liu Y

更新日期：2017-12-12 00:00:00

abstract：:The network meta-analysis was conducted to compare the short-term efficacy of different single-drug targeted therapies in the treatment of renal cell carcinoma (RCC). We initially searched databases for randomized controlled trials (RCTs) on different single-drug targeted therapies in treating RCC. The meta-analysis c...

journal_title：Bioscience reports

authors： He HL,Yao WX

更新日期：2017-12-07 00:00:00

abstract：:Folic acid (FA), which is necessary for normal cell division of mammals, has been implicated to be involved in many tumors. Dietary FA intake has been reported to be associated with a lower risk of nasopharyngeal cancer (NPC). However, the molecular mechanisms of FA in NPC cells remain unclear. In the present study, w...

journal_title：Bioscience reports

authors： Liu Z,Jin X,Pi W,Liu S

更新日期：2017-12-05 00:00:00

abstract：:miRNAs have been implicated in processing of cardiac hypoxia/reoxygenation (H/R)-induced injury. Recent studies demonstrated that miR-19a might provide a potential cardioprotective effect on myocardial disease. However, the effect of miR-19a in regulating myocardial ischemic injury has not been previously addressed. T...

journal_title：Bioscience reports

authors： Sun G,Lu Y,Li Y,Mao J,Zhang J,Jin Y,Li Y,Sun Y,Liu L,Li L

更新日期：2017-12-05 00:00:00

abstract：:The ubiquitin-proteasome system (UPS)-dependent proteolysis plays a major role in the muscle catabolic action of glucocorticoids (GCs). Atrogin-1 and muscle-specific RING finger protein 1 (MuRF1), two E3 ubiquitin ligases, are uniquely expressed in muscle. It has been previously demonstrated that GC treatment induced ...

journal_title：Bioscience reports

authors： Wang XJ,Xiao JJ,Liu L,Jiao HC,Lin H

更新日期：2017-11-17 00:00:00

abstract：:The purpose of the study is to investigate the correlation between the expression of C-reactive protein (CRP) and autophagy-related 9B (ATG9B) and pathological features of clear cell renal cell carcinoma (CCRCC) patients. We also intended to explore the effects of manipulated expression of CRP and ATG9B on the apoptos...

journal_title：Bioscience reports

authors： Ma Z,Qi Z,Shan Z,Li J,Yang J,Xu Z

更新日期：2017-11-15 00:00:00

abstract：:Guanylate kinase is an essential and conserved enzyme in nucleotide biosynthetic pathway that transfers phosphoryl group of ATP to GMP for yielding GDP. Here, we report the phosphorylation of guanylate kinase from Mycobacterium tuberculosis (mGmk) by eukaryotic-type Ser/Thr kinase, PknA. Mass spectrometric studies ide...

journal_title：Bioscience reports

authors： S Yadav G,K Ravala S,Kachhap S,Thakur M,Roy A,Singh B,Karthikeyan S,K Chakraborti P

更新日期：2017-11-15 00:00:00

abstract：:Doxorubicin (DOX) resistance in breast cancer largely results from the breast cancer stem cell like cells (BCSCs) which could be targetted to improve the efficacy of chemotherapy. Cell permeabilization using microbubbles (MBs) and ultrasound (US) have the potential for delivering molecules into the cytoplasm. We aim t...

journal_title：Bioscience reports

authors： Guo L,Zheng P,Fan H,Wang H,Xu W,Zhou W

更新日期：2017-11-09 00:00:00

abstract：:Gastric cancer (GC) is one of the most prevalent gastrointestinal malignancies. Long noncoding RNA (lncRNA) DANCR is a newly identified oncogenic lncRNA. However, the functional role and underlying molecular mechanisms of DANCR involved in GC progress remain unclear. In the present study, we investigated the biologica...

journal_title：Bioscience reports

authors： Mao Z,Li H,Du B,Cui K,Xing Y,Zhao X,Zai S

更新日期：2017-11-06 00:00:00

abstract：:Facioscapulohumeral muscular dystrophy (FSHD) region gene 1 (FRG1) is a candidate gene for FSHD. FRG1 regulates various muscle-related functions, but studies have proposed its role in development and angiogenesis also, where it is involved with tumor-associated molecules. Therefore, we decided to look into its role in...

journal_title：Bioscience reports

authors： Tiwari A,Pattnaik N,Mohanty Jaiswal A,Dixit M

更新日期：2017-10-27 00:00:00

abstract：:Peri-implantitis, which is characterized by dense inflammatory infiltrates and increased osteoclast activity, can lead to alveolar bone destruction and implantation failure. miRNAs participate in the regulation of various inflammatory diseases, such as periodontitis and osteoporosis. Therefore, the present study aimed...

journal_title：Bioscience reports

authors： Wu X,Chen X,Mi W,Wu T,Gu Q,Huang H

更新日期：2017-10-11 00:00:00

abstract：:Our study aimed at exploring the effects of miR-211 on the proliferation and apoptosis of lens epithelial cells in diabetic cataract mice by targetting NAD+-dependent histone deacetylase sirtulin 1 (SIRT1). Healthy male mice were assigned into normal and diabetic cataract groups. Blood glucose, lens turbidity, and apo...

journal_title：Bioscience reports

authors： Zeng K,Feng QG,Lin BT,Ma DH,Liu CM

更新日期：2017-07-27 00:00:00

abstract：:Emerging evidence are accumulating that long noncoding RNAs (lncRNAs) have recently been identified to participate in various cellular processes. Terminal differentiation induced ncRNA (TINCR) is a newly identified lncRNA with its functional roles not fully elucidated in human malignancy. The current study aims to ide...

journal_title：Bioscience reports

authors： Tian F,Xu J,Xue F,Guan E,Xu X

更新日期：2017-07-27 00:00:00

abstract：:Artocarpus incisa (breadfruit) seeds contain three different lectins (Frutalin, Frutapin (FTP) and Frutackin) with distinct carbohydrate specificities. The most abundant lectin is Frutalin, an α-D-galactose-specific carbohydrate-binding glycoprotein with antitumour properties and potential for tumour biomarker discove...

journal_title：Bioscience reports

authors： de Sousa FD,da Silva BB,Furtado GP,Carneiro IS,Lobo MDP,Guan Y,Guo J,Coker AR,Lourenzoni MR,Guedes MIF,Owen JS,Abraham DJ,Monteiro-Moreira ACO,Moreira RA

更新日期：2017-07-21 00:00:00

abstract：:Many miRNAs play critical roles in modulating various biological processes of osteoclast differentiation and function. Microphthalmia-associated transcription factor (MITF), a target of miR-340, served as pivotal transcription factor involved in osteoclast differentiation. However, the role of miR-340 and MITF during ...

journal_title：Bioscience reports

authors： Zhao H,Zhang J,Shao H,Liu J,Jin M,Chen J,Huang Y

更新日期：2017-07-20 00:00:00

abstract：:Signal transducer and activator of transcription (STAT), a family of latent cytoplasmic transcription factors, are composed of seven identified members (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). STATs are associated with several biological processes such as cell proliferation, invasion, and metastasis in var...

journal_title：Bioscience reports

authors： Li S,Sheng B,Zhao M,Shen Q,Zhu H,Zhu X

更新日期：2017-07-16 00:00:00

abstract：:The exon junction complex (EJC) is the main mechanism by which cells select specific mRNAs for translation into protein. We hypothesized that the EJC is involved in the regulation of gene expression during the stress response in cardiac myocytes, with implications for the failing heart. In cultured rat neonatal myocyt...

journal_title：Bioscience reports

authors： Pierrat OA,Paudyal A,Woodruff J,Koroleva O,Boateng SY

更新日期：2017-07-07 00:00:00

abstract：:Since the Protein Data Bank (PDB) was founded in 1971, there are now over 120,000 depositions, the majority of which are from X-ray crystallography and 90% of those made use of synchrotron beamlines. At the Cambridge Structure Database (CSD), founded in 1965, there are more than 800,000 'small molecule' crystal struct...

journal_title：Bioscience reports

authors： Helliwell JR

更新日期：2017-07-04 00:00:00

abstract：:Microvirin (MVN) is a carbohydrate-binding protein which shows high specificity for high-mannose type N-glycan structures. In the present study, we tried to identify whether MVN could bind to high-mannose containing hepatitis C virus (HCV) envelope glycoproteins, which are heavily decorated high-mannose glycans. In ad...

journal_title：Bioscience reports

authors： Min YQ,Duan XC,Zhou YD,Kulinich A,Meng W,Cai ZP,Ma HY,Liu L,Zhang XL,Voglmeir J

更新日期：2017-06-30 00:00:00

abstract：:The study aims to explore the effects of miR-135b-5p on myocardial ischemia/reperfusion (I/R) injuries by regulating Janus protein tyrosine kinase 2 (JAK2)/signal transducer and activator of transcription (STAT) signaling pathway by mediating inhalation anesthesia with sevoflurane. A sum of 120 healthy Wistar male mic...

journal_title：Bioscience reports

authors： Xie XJ,Fan DM,Xi K,Chen YW,Qi PW,Li QH,Fang L,Ma LG

更新日期：2017-06-27 00:00:00

abstract：:The present study estimates the effect of rivaroxaban on preventing deep vein thrombosis (DVT) in aged diabetics with femoral neck fractures after hip replacement. Our study consisted of 236 aged diabetics with femoral neck fractures, which were divided into the rivaroxaban and control groups. Reaction time (R time), ...

journal_title：Bioscience reports

authors： Zhang YM,Jiang X,Sun YS

更新日期：2017-06-21 00:00:00

abstract：:Secretion of high molecular weight (HMW) adiponectin is dependent on post-translational modification (PTM) of conserved lysines in the collagenous domain. The present study aims to characterize the enzymes responsible for the PTM of conserved lysines which leads to HMW adiponectin secretion, and to define its signific...

journal_title：Bioscience reports

authors： Webster JA,Yang Z,Kim YH,Loo D,Mosa RM,Li H,Chen C

更新日期：2017-05-17 00:00:00

abstract：:The affinity of epigallocatechin gallate (EGCG) for human serum albumin (HSA) was measured in physiological conditions using NMR and isothermal titration calorimetry (ITC). NMR estimated the Ka (self-dissociation constant) of EGCG as 50 mM. NMR showed two binding events: strong (n1=1.8 ± 0.2; Kd1 =19 ± 12 μM) and weak...

journal_title：Bioscience reports

authors： Eaton JD,Williamson MP

更新日期：2017-05-11 00:00:00

abstract：:Microparticles (MPs) and miRNAs have been shown to play important roles in coronary artery disease (CAD) by monitoring endothelial dysfunction. The present study aims to investigate the diagnostic value of endothelial MPs (EMPs) and miRNAs (miR-92a or miR-23a) as biomarkers in distinguishing patients with acute myocar...

journal_title：Bioscience reports

authors： Zhang Y,Cheng J,Chen F,Wu C,Zhang J,Ren X,Pan Y,Nie B,Li Q,Li Y

更新日期：2017-03-27 00:00:00

abstract：:The emergence of multidrug-resistant (MDR) microbes caused by overuse of antibiotics leads to urgent demands for novel antibiotics exploration. Our recent data showed that Ly2.1-3 (a novel lymphocyte antigen 6 (Ly6) gene cluster) were proteins with cationic nature and rich in cysteine content, that are characteristic ...

journal_title：Bioscience reports

authors： Liu X,Cao X,Wang S,Ji G,Zhang S,Li H

更新日期：2017-01-17 00:00:00

abstract：:Bifunctional dihaem cytochrome c thiosulfate dehydrogenases/tetrathionate reductases (TsdA) exhibit different catalytic properties depending on the source organism. In the human food-borne intestinal pathogen Campylobacter jejuni, TsdA functions as a tetrathionate reductase enabling respiration with tetrathionate as a...

journal_title：Bioscience reports

authors： Kurth JM,Butt JN,Kelly DJ,Dahl C

更新日期：2016-12-09 00:00:00

abstract：:Extracorporeal pulsed electromagnetic field (PEMF) has shown the ability to regenerate tissue by promoting cell proliferation. In the present study, we investigated for the first time whether PEMF treatment could improve the myocardial ischaemia/reperfusion (I/R) injury and uncovered its underlying mechanisms.In our s...

journal_title：Bioscience reports

authors： Ma F,Li W,Li X,Tran BH,Suguro R,Guan R,Hou C,Wang H,Zhang A,Zhu Y,Zhu Y

更新日期：2016-12-05 00:00:00

abstract：:The preadipocyte differentiation biological process involves a cascade of transcriptional events that culminates in the expression of peroxisome proliferator-activated receptor (PPAR) γ. The differentiation cocktail [insulin (INS), dexamethasone (DEX) and isobutylmethylxanthine (IBMX)] can induce preadipocyte differen...

journal_title：Bioscience reports

authors： Cheng B,Wu M,Xu S,Zhang X,Wang Y,Wang N,Leng L,Li H

更新日期：2016-11-03 00:00:00

abstract：:Interleukins (ILs) are the most typical inflammatory and immunoregulatory cytokines. Evidences have shown that polymorphisms in ILs are associated with cerebral infarction risk. However, the results remain inconclusive. The present study was to evaluate the role of ILs polymorphisms in cerebral infarction susceptibili...

journal_title：Bioscience reports

authors： Wang J,Fan N,Deng Y,Zhu J,Mei J,Chen Y,Yang H

更新日期：2016-11-03 00:00:00

abstract：:Hippo pathway is a highly conservative signalling pathway related to the development of organisms, which has been demonstrated to be strongly linked to the tumorigenesis and tumour progression. As the major downstream effector of Hippo pathway, yes-associated protein (YAP), is a transcriptional activator of target gen...

journal_title：Bioscience reports

authors： Wang S,Ma K,Chen L,Zhu H,Liang S,Liu M,Xu N

更新日期：2016-09-29 00:00:00

abstract：:To observe the effect of gene expression and tumorigenicity in hybrid cells of human embryonic stem cells (hESCs) and ovarian cancer cells in vitro and in vivo using a mouse model, and to determine its feasibility in reprogramming tumour cells growth and apoptosis, for a potential exploration of the role of hESCs and ...

journal_title：Bioscience reports

authors： He K,Qu H,Xu LN,Gao J,Cheng FY,Xiang P,Zhou CQ

更新日期：2016-09-16 00:00:00

abstract：:High concentrations of glucose and palmitate increase endothelial cell inflammation and apoptosis, events that often precede atherogenesis. They may do so by decreasing basal autophagy and AMP-activated protein kinase (AMPK) activity, although the mechanisms by which this occurs are not clear. Decreased function of th...

journal_title：Bioscience reports

authors： Weikel KA,Cacicedo JM,Ruderman NB,Ido Y

更新日期：2016-09-16 00:00:00

abstract：:miRNAs are non-coding RNA molecules typically 18-22 nucleotides long that can suppress the expression of their target genes. Several laboratories have attempted to identify miRNAs from the pig that are involved in Salmonella infection. These bioinformatics strategies using the newly available genomic sequence are gene...

journal_title：Bioscience reports

authors： Yao M,Gao W,Yang J,Liang X,Luo J,Huang T

更新日期：2016-08-31 00:00:00

abstract：:In the present study, we aimed to examine whether SET domain-containing methyltransferases are up-regulated in different classes of renal cell carcinoma. We immunoblotted against SET domain and quantified the expression of these modular domains. Furthermore, we examined the expression of Rad51, the key protein that co...

journal_title：Bioscience reports

authors： Liu S,Li Y,Xu H,Wang K,Li N,Li J,Sun T,Xu Y

更新日期：2016-06-30 00:00:00

abstract：:Recent experimental evidence increasingly shows that the dysregulation of cellular bioenergetics is associated with a wide array of common human diseases, including cancer, neurological diseases and diabetes. Respiration provides a vital source of cellular energy for most eukaryotic cells, particularly high energy dem...

journal_title：Bioscience reports

authors： Lal S,Alam MM,Hooda J,Shah A,Cao TM,Xuan Z,Zhang L

更新日期：2016-06-30 00:00:00

abstract：:Micro-inflammation plays an important role in the pathogenesis of spontaneously hypertensive rat (SHR). In the present study, we investigated the therapeutic potential of resveratrol (RSV), a polyphenol with anti-fibrosis activity in hypertensive renal damage model. In SHR renal damage model, RSV treatment blunted the...

journal_title：Bioscience reports

authors： Xue HY,Yuan L,Cao YJ,Fan YP,Chen XL,Huang XZ

更新日期：2016-06-03 00:00:00

abstract：:Coagulation factor IX (FIX) is an essential plasma protein for blood coagulation. The first epidermal growth factor (EGF) motif of FIX (EGF-F9) has been reported to attenuate cell adhesion to the extracellular matrix (ECM). The purpose of the present study was to determine the effects of this motif on cell adhesion an...

journal_title：Bioscience reports

authors： Ishikawa T,Kitano H,Mamiya A,Kokubun S,Hidai C

更新日期：2016-06-03 00:00:00

abstract：:Accumulating evidence demonstrates that long non-coding RNAs (LncRNAs) play important roles in regulating gene expression and are involved in various cancers, including colorectal cancer (CRC). However, LncRNA profiles in CRC remain largely unknown. The present study aims to find the key LncRNA associated with CRC and...

journal_title：Bioscience reports

authors： Sun L,Xue H,Jiang C,Zhou H,Gu L,Liu Y,Xu C,Xu Q

更新日期：2016-05-06 00:00:00